Beilstein J. Org. Chem.2011,7, 962–975, doi:10.3762/bjoc.7.108
substrate scope and leads to differentially substituted enantiopurepyridines in good to moderate yields. The preparation of diverse substituted lactic acid derived pyrid-4-yl nonaflates is described. Additional evidence for the postulated mechanism of the multicomponent reaction is presented.
Keywords
: allenes; enantiopurepyridines; ketoenamides; multicomponent reactions; nonaflates; Introduction
The pyridine core is ubiquitous in pharmacologically active agents, agrochemicals and natural products [1][2][3][4][5]. The HMG-CoA reductase inhibitors Glenvastatin and Cerivastatin are exemplarily mentioned
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Graphical Abstract
Scheme 1:
Preparation of β-ketoenamides and subsequent cyclocondensation to 4-hydroxypyridines. a) Et2O, −40 ...